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Behr, J. ; Kreuter, M.* ; Hoeper, M.M.* ; Wirtz, H.* ; Klotsche, J.* ; Koschel, D.* ; Andreas, S.* ; Claussen, M.* ; Grohe, C.* ; Wilkens, H.* ; Randerath, W.* ; Skowasch, D.* ; Meyer, F.J.* ; Kirschner, J.* ; Glaeser, S.* ; Herth, F.J.F.* ; Welte, T.* ; Huber, R.M.* ; Neurohr, C.* ; Schwaiblmair, M.* ; Kohlhaeufl, M.* ; Hoeffken, G.* ; Held, M.* ; Koch, A.* ; Bahmer, T.* ; Pittrow, D.*

Management of patients with idiopathic pulmonary fibrosis in clinical practice: The INSIGHTS-IPF registry.

Eur. Respir. J. 46, 186-196 (2015)
Verlagsversion Anhang DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
After introduction of the new international guidelines on idiopathic pulmonary fibrosis (IPF) in 2011, we investigated clinical management practices for patients with IPF according to physicians' diagnoses. A prospective, multicenter, noninterventional study with comprehensive quality measures including on-site source data verification was performed in Germany. 502 consecutive patients (171 newly diagnosed, 331 prevalent; mean+-/SD age 68.7+-/9.4 years, 77.9% males) with a mean disease duration of 2.3+-/3.5 years were enrolled. IPF diagnosis was based on clinical assessments and high-resolution computed tomography (HRCT) in 90.2%, and on surgical lung biopsy combined with histology in 34.1% (lavage in 61.8%). The median 6-min walk distance was 320 m (mean 268+-/200 m). The mean forced vital capacity was 72+-/20% pred and diffusing capacity of the lung for carbon monoxide was 35+-/15% pred. No drugs were administered in 17.9%, oral steroids in 23.7%, N-acetylcysteine in 33.7%, pirfenidone in 44.2% and other drugs in 4.6% of patients. Only 2.8% of the cohort was listed for lung transplantation. IPF patients were diagnosed in line with the new guidelines. They had more severe disease than those enrolled in recent randomised controlled trials. In addition to HRCT, the frequency of lung biopsies was surprisingly high. Treatment patterns varied substantially.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Lung-function Tests; Respiratory Society; Diagnosis; Statement; Alveolitis; Guidelines; Equations; Therapy; Values; Trial
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 0903-1936
e-ISSN 1399-3003
Zeitschrift European Respiratory Journal
Quellenangaben Band: 46, Heft: 1, Seiten: 186-196 Artikelnummer: , Supplement: ,
Verlag European Respiratory Society
Verlagsort Sheffield
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Lung Research
PSP-Element(e) G-501600-002
DOI 10.1183/09031936.00217614
WOS ID WOS:000357137300023
Erfassungsdatum 2015-02-20
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