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Pinto-Teixeira, F.* ; Viader Llargues, O.* ; Torres-Mejia, E.* ; Turan, M.* ; Gonzalez-Gualda, E.* ; Pola-Morell, L.* ; López-Schier, H.

Inexhaustible hair-cell regeneration in young and aged zebrafish.

Biol. Open 4, 903-909 (2015)
Verlagsversion Anhang DOI
Open Access Gold
Creative Commons Lizenzvertrag
Animals have evolved two general strategies to counter injury and maintain physiological function. The most prevalent is protection by isolating vital organs into body cavities. However, protection is not optimal for sensory systems because their external components need to be exposed to the environment to fulfill their receptive function. Thus, a common strategy to maintain sensory abilities against persistent environmental insult involves repair and regeneration. However, whether age or frequent injuries affect the regenerative capacity of sensory organs remains unknown. We have found that neuromasts of the zebrafish lateral line regenerate mechanosensory hair cells after recurrent severe injuries and in adulthood. Moreover, neuromasts can reverse transient imbalances of Notch signaling that result in defective organ proportions during repair. Our results reveal inextinguishable hair-cell regeneration in the lateral line, and suggest that the neuromast epithelium is formed by plastic territories that are maintained by continuous intercellular communication.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Adult ; Hair Cells ; Lateral Line ; Notch ; Regeneration ; Self Organization; Lateral-line; Gene-expression; Enhancer Trap; Sensory Organ; Stem-cells; Notch; Sox2; Neuromasts
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
e-ISSN 2046-6390
Zeitschrift Biology Open
Quellenangaben Band: 4, Heft: 7, Seiten: 903-909 Artikelnummer: , Supplement: ,
Verlag Company of Biologists
Verlagsort Cambridge
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Sensory Biology and Organogenesis (SBO)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-500100-001
DOI 10.1242/bio.012112
WOS ID WOS:000357943800018
Scopus ID 84979988053
Erfassungsdatum 2015-08-07
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