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Petzold, A. ; Solimena, M. ; Knoch, K.-P.

Mechanisms of beta cell dysfunction associated with viral infection.

Curr. Diab. Rep. 15:654 (2015)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Type 1 diabetes (T1D) results from genetic predisposition and environmental factors leading to the autoimmune destruction of pancreatic beta cells. Recently, a rapid increase in the incidence of childhood T1D has been observed worldwide; this is too fast to be explained by genetic factors alone, pointing to the spreading of environmental factors linked to the disease. Enteroviruses (EVs) are perhaps the most investigated environmental agents in relationship to the pathogenesis of T1D. While several studies point to the likelihood of such correlation, epidemiological evidence in its support is inconclusive or in some instances even against it. Hence, it is still unknown if and how EVs are involved in the development of T1D. Here we review recent findings concerning the biology of EV in beta cells and the potential implications of this knowledge for the understanding of beta cell dysfunction and autoimmune destruction in T1D.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Type 1 Diabetes ; Beta Cell ; Enterovirus ; Coxsackievirus
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 1534-4827
e-ISSN 1539-0829
Zeitschrift Current Diabetes Reports
Quellenangaben Band: 15, Heft: 10, Seiten: , Artikelnummer: 654 Supplement: ,
Verlag Springer
Verlagsort Heidelberg [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502600-001
PubMed ID 26280364
DOI 10.1007/s11892-015-0654-x
WOS ID WOS:000361488100007
Erfassungsdatum 2015-08-20
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