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Han, Y. ; Tzoumas, S. ; Nunes, A. ; Ntziachristos, V. ; Rosenthal, A.

Sparsity-based acoustic inversion in cross-sectional multiscale optoacoustic imaging.

Med. Phys. 42, 5444-5452 (2015)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
PURPOSE: With recent advancement in hardware of optoacoustic imaging systems, highly detailed cross-sectional images may be acquired at a single laser shot, thus eliminating motion artifacts. Nonetheless, other sources of artifacts remain due to signal distortion or out-of-plane signals. The purpose of image reconstruction algorithms is to obtain the most accurate images from noisy, distorted projection data. METHODS: In this paper, the authors use the model-based approach for acoustic inversion, combined with a sparsity-based inversion procedure. Specifically, a cost function is used that includes the L1 norm of the image in sparse representation and a total variation (TV) term. The optimization problem is solved by a numerically efficient implementation of a nonlinear gradient descent algorithm. TV-L1 model-based inversion is tested in the cross section geometry for numerically generated data as well as for in vivo experimental data from an adult mouse. RESULTS: In all cases, model-based TV-L1 inversion showed a better performance over the conventional Tikhonov regularization, TV inversion, and L1 inversion. In the numerical examples, the images reconstructed with TV-L1 inversion were quantitatively more similar to the originating images. In the experimental examples, TV-L1 inversion yielded sharper images and weaker streak artifact. CONCLUSIONS: The results herein show that TV-L1 inversion is capable of improving the quality of highly detailed, multiscale optoacoustic images obtained in vivo using cross-sectional imaging systems. As a result of its high fidelity, model-based TV-L1 inversion may be considered as the new standard for image reconstruction in cross-sectional imaging.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter L1 Minimization ; Model-based Reconstruction ; Optoacoustic Imaging ; Regularization ; Total Variation; Tomography In-vivo; Photoacoustic Tomography; Reconstruction; Algorithm; Deconvolution; Detectors; Images; Noise; Array
ISSN (print) / ISBN 0094-2405
e-ISSN 1522-8541
Zeitschrift Medical Physics
Quellenangaben Band: 42, Heft: 9, Seiten: 5444-5452 Artikelnummer: , Supplement: ,
Verlag American Institute of Physics (AIP)
Verlagsort Melville
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)