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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Fgf15 regulates thalamic development by controlling the expression of proneural genes.
Brain Struct. Funct. 221, 3095-3109 (2015)
The establishment of the brain structural complexity requires a precisely orchestrated interplay between extrinsic and intrinsic signals modulating cellular mechanisms to guide neuronal differentiation. However, little is known about the nature of these signals in the diencephalon, a complex brain region that processes and relays sensory and motor information to and from the cerebral cortex and subcortical structures. Morphogenetic signals from brain organizers regulate histogenetic processes such as cellular proliferation, migration, and differentiation. Sonic hedgehog (Shh) in the key signal of the ZLI, identified as the diencephalic organizer. Fgf15, the mouse gene orthologous of human, chick, and zebrafish Fgf19, is induced by Shh signal and expressed in the diencephalic alar plate progenitors during histogenetic developmental stages. This work investigates the role of Fgf15 signal in diencephalic development. In the absence of Fgf15, the complementary expression pattern of proneural genes: Ascl1 and Nng2, is disrupted and the GABAergic thalamic cells do not differentiate; in addition dorsal thalamic progenitors failed to exit from the mitotic cycle and to differentiate into neurons. Therefore, our findings indicate that Fgf15 is the Shh downstream signal to control thalamic regionalization, neurogenesis, and neuronal differentiation by regulating the expression and mutual segregation of neurogenic and proneural regulatory genes.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Diencephalon ; Thalamus ; Regionalization ; Zli ; Fgf15 ; Shh; Zona Limitans Intrathalamica; Fibroblast Growth-factors; Developing Rat Thalamus; Sonic-hedgehog; Molecular Regionalization; Isthmic Organizer; Mouse Embryo; Chick Fgf19; Neurons; Identity
ISSN (print) / ISBN
1863-2653
e-ISSN
1863-2661
Zeitschrift
Brain Structure & Function
Quellenangaben
Band: 221,
Heft: 6,
Seiten: 3095-3109
Verlag
Springer
Verlagsort
Berlin ; Heidelberg
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Developmental Genetics (IDG)