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Spatiotemporal expression control correlates with intragenic scaffold matrix attachment regions (S/MARs) in Arabidopsis thaliana.
PLoS Comput. Biol. 2, 136-145:e21 (2006)
Scaffold/matrix attachment regions (S/MARs) are essential for structural organization of the chromatin within the nucleus and serve as anchors of chromatin loop domains. A significant fraction of genes in Arabidopsis thaliana contains intragenic S/MAR elements and a significant correlation of S/MAR presence and overall expression strength has been demonstrated. In this study, we undertook a genome scale analysis of expression level and spatiotemporal expression differences in correlation with the presence or absence of genic S/MAR elements. We demonstrate that genes containing intragenic S/MARs are prone to pronounced spatiotemporal expression regulation. This characteristic is found to be even more pronounced for transcription factor genes. Our observations illustrate the importance of S/MARs in transcriptional regulation and the role of chromatin structural characteristics for gene regulation. Our findings open new perspectives for the understanding of tissue- and organ-specific regulation of gene expression.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
FLORAL ORGAN IDENTITY; NUCLEAR ARCHITECTURE; GENE-EXPRESSION; TRANSCRIPTION FACTORS; HISTONE ACETYLATION; CHROMATIN LOOPS; GENOME; SATB1; ELEMENTS; DNA
ISSN (print) / ISBN
1553-734X
e-ISSN
1553-7358
Zeitschrift
PLoS Computational Biology
Quellenangaben
Band: 2,
Heft: 3,
Seiten: 136-145,
Artikelnummer: e21
Verlag
Public Library of Science (PLoS)
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed