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Schirawski, J.* ; Mannhaupt, G. ; Münch, K.* ; Brefort, T.* ; Schipper, K.* ; Doehlemann, G.* ; di Stasio, M.* ; Rössel, N.* ; Mendoza-Mendoza, A.* ; Pester, D.* ; Müller, O.* ; Winterberg, B.* ; Meyer, E.* ; Ghareeb, H.* ; Wollenberg, T.* ; Münsterkötter, M. ; Wong, P. ; Walter, M. ; Stukenbrock, E.* ; Güldener, U. ; Kahmann, R.*

Pathogenicity determinants in smut fungi revealed by genome comparison.

Science 330, 1546-1548 (2010)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Biotrophic pathogens, such as the related maize pathogenic fungi Ustilago maydis and Sporisorium reilianum, establish an intimate relationship with their hosts by secreting protein effectors. Because secreted effectors interacting with plant proteins should rapidly evolve, we identified variable genomic regions by sequencing the genome of S. reilianum and comparing it with the U. maydis genome. We detected 43 regions of low sequence conservation in otherwise well-conserved syntenic genomes. These regions primarily encode secreted effectors and include previously identified virulence clusters. By deletion analysis in U. maydis, we demonstrate a role in virulence for four previously unknown diversity regions. This highlights the power of comparative genomics of closely related species for identification of virulence determinants.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Ustilago-maydis; Sporisorium; Maize
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Zeitschrift Science
Quellenangaben Band: 330, Heft: 6010, Seiten: 1546-1548 Artikelnummer: , Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed