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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Risk Variants for Atrial Fibrillation on Chromosome 4q24 Associate with Ischemic Stroke.
Ann. Neurol. 64, 402-409 (2008)
Elucidation of the entire human genomic sequence is one of the greatest achievements of science. Understanding the functional role of 30,000 human genes and more than 2 million polymorphisms was possible through a multidisciplinary approach using microarrays and bioinformatics. Polymorphisms, variations in DNA sequences, occur in 1% of the population, and a vast majority of them are single nucleotide polymorphisms. Genotype analysis has identified genes important in thrombosis, cardiac defects, and risk of cardiac disease. Many of the genes show a significant correlation with polymorphisms and the incidence of coronary artery disease and heart failure. In this chapter, the application of current state-of-the-art genomic analysis to a variety of these disorders is reviewed.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0364-5134
e-ISSN
1531-8249
Zeitschrift
Annals of Neurology
Quellenangaben
Band: 64,
Heft: 4,
Seiten: 402-409
Verlag
Wiley
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Epidemiology (EPI)