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Chekkoury, A. ; Gateau, J. ; Driessen, W.H.P. ; Symvoulidis, P. ; Bézière, N. ; Feuchtinger, A. ; Walch, A.K. ; Ntziachristos, V.

Optical mesoscopy without the scatter: Broadband multispectral optoacoustic mesoscopy.

Biomed. Opt. Express 6, 3134-3148 (2015)
Verlagsversion DOI PMC
Open Access Gold
Optical mesoscopy extends the capabilities of biological visualization beyond the limited penetration depth achieved by microscopy. However, imaging of opaque organisms or tissues larger than a few hundred micrometers requires invasive tissue sectioning or chemical treatment of the specimen for clearing photon scattering, an invasive process that is regardless limited with depth. We developed previously unreported broadband optoacoustic mesoscopy as a tomographic modality to enable imaging of optical contrast through several millimeters of tissue, without the need for chemical treatment of tissues. We show that the unique combination of three-dimensional projections over a broad 500 kHz-40 MHz frequency range combined with multi-wavelength illumination is necessary to render broadband multispectral optoacoustic mesoscopy (2B-MSOM) superior to previous optical or optoacoustic mesoscopy implementations.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Multispectral And Hyperspectral Imaging; Photoacoustic Imaging; Photoacoustics; Tomographic Imaging; Spectral Discrimination; High-Resolution; In-Vivo; 3-Dimensional Visualization; Photoacoustic Tomography; Mouse-Brain; Microscopy; Scanner; Ultramicroscopy; Quantification; Reconstruction
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 2156-7085
e-ISSN 2156-7085
Zeitschrift Biomedical Optics Express
Quellenangaben Band: 6, Heft: 9, Seiten: 3134-3148 Artikelnummer: , Supplement: ,
Verlag Optical Society of America (OSA)
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
Institute of Pathology (PATH)
Research Unit Analytical Pathology (AAP)
POF Topic(s) 30205 - Bioengineering and Digital Health
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505500-001
G-500300-001
G-500390-001
PubMed ID 26417486
DOI 10.1364/BOE.6.003134
WOS ID WOS:000360888400001
Scopus ID 84948753895
Erfassungsdatum 2015-10-02
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