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de Miguel-Yanes, J.M.* ; Shrader, P.* ; Pencina, M.J.* ; Fox, C.S.* ; Manning, A.K.* ; Grant, R.W.* ; Dupuis, J.* ; Florez, J.C* ; D'Agostino, R.B, Sr.* ; Cupples, L.A.* ; Meigs, J.B* ; MAGIC Investigators (Grallert, H. ; Meisinger, C. ; Gieger, C. ; Thorand, B. ; Wichmann, H.-E. ; Illig, T.) ; DIAGRAM Consortium (Huth, C. ; Grallert, H. ; Gieger, C. ; Klopp, N. ; Petersen, A.-K. ; Thorand, B. ; Wichmann, H.-E. ; Illig, T.)

Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.

Diabetes Care 34, 121-125 (2011)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
To test if knowledge of type 2 diabetes genetic variants improves disease prediction. We tested 40 single nucleotide polymorphisms (SNPs) associated with diabetes in 3,471 Framingham Offspring Study subjects followed over 34 years using pooled logistic regression models stratified by age (<50 years, diabetes cases = 144; or ≥50 years, diabetes cases = 302). Models included clinical risk factors and a 40-SNP weighted genetic risk score. We tested 40 single nucleotide polymorphisms (SNPs) associated with diabetes in 3,471 Framingham Offspring Study subjects followed over 34 years using pooled logistic regression models stratified by age (<50 years, diabetes cases = 144; or ≥50 years, diabetes cases = 302). Models included clinical risk factors and a 40-SNP weighted genetic risk score. Knowledge of common genetic variation appropriately reclassifies younger people for type 2 diabetes risk beyond clinical risk factors but not older people.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter association analysis; susceptibility loci; variants; mellitus
Sprache englisch
Veröffentlichungsjahr 2011
HGF-Berichtsjahr 2011
ISSN (print) / ISBN 0149-5992
e-ISSN 1935-5548
Zeitschrift Diabetes Care
Quellenangaben Band: 34, Heft: 1, Seiten: 121-125 Artikelnummer: , Supplement: ,
Verlag American Diabetes Association
Verlagsort Alexandria, Va.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Research Unit Molecular Epidemiology (AME)
POF Topic(s) 30202 - Environmental Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-002
G-504200-002
PubMed ID 20889853
DOI 10.2337/dc10-1265
Erfassungsdatum 2011-05-25
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