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CARDIoGRAMplusC4D Consortium (Nikpay, M.* ; Goel, A.* ; Won, H.* ; Hall, L.M.* ; Willenborg, C.* ; Kanoni, S.* ; Saleheen, D.* ; Gieger, C. ; Meitinger, T. ; Peters, A. ; Watkins, H.* ; Kathiresan, S.* ; MacPherson, R.*)

A comprehensive 1000 genomes–based genome-wide association meta-analysis of coronary artery disease.

Nat. Genet. 47, 1121-1130 (2015)
Anhang Forschungsdaten DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of ∼185,000 CAD cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 million low-frequency (0.005 < MAF < 0.05) variants. In addition to confirming most known CAD-associated loci, we identified ten new loci (eight additive and two recessive) that contain candidate casual genes newly implicating biological processes in vessel walls. We observed intralocus allelic heterogeneity but little evidence of low-frequency variants with larger effects and no evidence of synthetic association. Our analysis provides a comprehensive survey of the fine genetic architecture of CAD, showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Zeitschrift Nature Genetics
Quellenangaben Band: 47, Heft: 10, Seiten: 1121-1130 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)
Institute of Genetic Epidemiology (IGE)
POF Topic(s) 30202 - Environmental Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
90000 - German Center for Diabetes Research
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504091-004
G-504000-001
G-500700-001
G-504100-001
G-501900-402
DOI 10.1038/ng.3396
WOS ID WOS:000361969900007
Scopus ID 84942987885
Scopus ID 84940932825
Erfassungsdatum 2015-10-07
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