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Systemic first-line phenotyping.
Methods Mol. Biol. 530, 463-509 (2009)
With the completion of the mouse genome sequence an essential task for biomedical sciences in the twenty-first century will be the generation and functional analysis of mouse models for every gene in the mammalian genome. More than 30,000 mutations in ES cells will be engineered and thousands of mouse disease models will become available over the coming years by the collaborative effort of the International Mouse Knockout Consortium. In order to realize the full value of the mouse models proper characterization, archiving and dissemination of mouse disease models to the research community have to be performed. Phenotyping centers (mouse clinics) provide the necessary capacity, broad expertise, equipment, and infrastructure to carry out large-scale systemic first-line phenotyping. Using the example of the German Mouse Clinic (GMC) we will introduce the reader to the different aspects of the organization of a mouse clinic and present selected methods used in first-line phenotyping.
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Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
englisch
Veröffentlichungsjahr
2009
HGF-Berichtsjahr
0
ISSN (print) / ISBN
1064-3745
e-ISSN
1940-6029
Konferenztitel
Gene Knockout Protocols
Zeitschrift
Methods in Molecular Biology
Quellenangaben
Band: 530,
Seiten: 463-509
Verlag
Springer
Verlagsort
Berlin [u.a.]
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Experimental Genetics (IEG)
Institute of Pathology (PATH)
Institute of Developmental Genetics (IDG)
Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Virology (VIRO)
Institute for Allergy Research (IAF)
Institute of Molecular Immunology (IMI)
Institute of Epidemiology (EPI)
Institute of Pathology (PATH)
Institute of Developmental Genetics (IDG)
Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Virology (VIRO)
Institute for Allergy Research (IAF)
Institute of Molecular Immunology (IMI)
Institute of Epidemiology (EPI)
POF Topic(s)
30201 - Metabolic Health
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30204 - Cell Programming and Repair
30203 - Molecular Targets and Therapies
30202 - Environmental Health
30503 - Chronic Diseases of the Lung and Allergies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30204 - Cell Programming and Repair
30203 - Molecular Targets and Therapies
30202 - Environmental Health
30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er)
Genetics and Epidemiology
Enabling and Novel Technologies
Immune Response and Infection
Allergy
Enabling and Novel Technologies
Immune Response and Infection
Allergy
PSP-Element(e)
G-500600-001
G-500300-001
G-500500-001
G-505600-001
G-502700-001
G-505400-001
G-501793-001
G-500500-002
G-500600-003
G-503900-003
G-500300-001
G-500500-001
G-505600-001
G-502700-001
G-505400-001
G-501793-001
G-500500-002
G-500600-003
G-503900-003
Erfassungsdatum
2009-12-31