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EBNA2 and its coactivator EBNA-LP.
Curr. Top. Microbiol. Immunol. 391, 35-39 (2015)
While all herpesviruses can switch between lytic and latent life cycle, which are both driven by specific transcription programs, a unique feature of latent EBV infection is the expression of several distinct and well-defined viral latent transcription programs called latency I, II, and III. Growth transformation of B-cells by EBV in vitro is based on the concerted action of Epstein-Barr virus nuclear antigens (EBNAs) and latent membrane proteins(LMPs). EBV growth-transformed B-cells express a viral transcriptional program, termed latency III, which is characterized by the coexpression of EBNA2 and EBNA-LP with EBNA1, EBNA3A, -3B, and -3C as well as LMP1, LMP2A, and LMP2B. The focus of this review will be to discuss the current understanding of how two of these proteins, EBNA2 and EBNA-LP, contribute to EBV-mediated B-cell growth transformation.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Herausgeber
Münz, C.*
Schlagwörter
Epstein-barr-virus; Latent Membrane-protein; Lymphoblastoid Cell-lines; Signal-binding-protein; Antigen Leader Protein; Rbp-j-kappa; Nuclear-protein-2 Acidic Domain; Responsive Cis-element; Motor-neuron Protein; Human B-lymphocytes
ISSN (print) / ISBN
0070-217x
e-ISSN
0070-217X
Konferenztitel
Epstein Barr Virus Volume 2
Zeitschrift
Current Topics in Microbiology and Immunology
Quellenangaben
Band: 391,
Seiten: 35-39
Verlag
Springer
Verlagsort
Berlin ; Heidelberg [u.a.]
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Research Unit Gene Vector (AGV)