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Nat. Genet. 43, 1082-1090 (2011)
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
36.377
6.716
264
321
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
obstructive pulmonary-disease; genetic-variation; blood-pressure; variants; metaanalysis; risk; protein; polymorphisms; population; expression
Sprache
englisch
Veröffentlichungsjahr
2011
HGF-Berichtsjahr
2011
ISSN (print) / ISBN
1061-4036
e-ISSN
1546-1718
Zeitschrift
Nature Genetics
Quellenangaben
Band: 43,
Heft: 11,
Seiten: 1082-1090
Verlag
Nature Publishing Group
Verlagsort
New York, NY
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Genetic Epidemiology (IGE)
Research Unit Molecular Epidemiology (AME)
Institute of Epidemiology (EPI)
Institute of Lung Health and Immunity (LHI)
Research Unit Molecular Epidemiology (AME)
Institute of Epidemiology (EPI)
Institute of Lung Health and Immunity (LHI)
POF Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30503 - Chronic Diseases of the Lung and Allergies
30202 - Environmental Health
30503 - Chronic Diseases of the Lung and Allergies
30202 - Environmental Health
Forschungsfeld(er)
Genetics and Epidemiology
Lung Research
Lung Research
PSP-Element(e)
G-504100-001
G-504200-001
G-503900-001
G-505000-003
G-504200-001
G-503900-001
G-505000-003
PubMed ID
21946350
DOI
10.1038/ng.941
WOS ID
WOS:000296584000011
Scopus ID
80055008094
Erfassungsdatum
2011-11-07