PuSH - Publikationsserver des Helmholtz Zentrums München: Genome-wide meta-analysis reveals common splice site acceptor variant in <em>CHRNA4</em> associated with nicotine dependence.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Hancock, D.B.* ; Reginsson, G.W.* ; Gaddis, N.C.* ; Chen, X.* ; Saccone, N.L.* ; Lutz, S.M.* ; Qaiser, B.* ; Sherva, R.* ; Steinberg, S.* ; Zink, F.* ; Stacey, S.N.* ; Glasheen, C.* ; Chen, J.* ; Gu, F.* ; Frederiksen, B.N.* ; Loukola, A.* ; Gudbjartsson, D.F.* ; Brüske, I. ; Landi, M.T.* ; Bickeböller, H.* ; Madden, P.* ; Farrer, L.A.* ; Kaprio, J.* ; Kranzler, H.R.* ; Gelernter, J.* ; Baker, T.B.* ; Kraft, P.* ; Amos, C.I.* ; Caporaso, N.E.* ; Hokanson, J.E.* ; Bierut, L.J.* ; Thorgeirsson, T.E.* ; Johnson, E.O.* ; Stefansson, K.*

Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.

Transl. Psychiatry 5:e651 (2015)

Verlagsversion

DOI

PMC

	Open Access Gold

Abstract
Metriken
Zusatzinfos

We conducted a 1000 Genomes-imputed genome-wide association study (GWAS) meta-analysis for nicotine dependence, defined by the Fagerström Test for Nicotine Dependence in 17 074 ever smokers from five European-ancestry samples. We followed up novel variants in 7469 ever smokers from five independent European-ancestry samples. We identified genome-wide significant association in the alpha-4 nicotinic receptor subunit (CHRNA4) gene on chromosome 20q13: lowest P=8.0 × 10 -9 across all the samples for rs2273500-C (frequency=0.15; odds ratio=1.12 and 95% confidence interval=1.08-1.17 for severe vs mild dependence). rs2273500-C, a splice site acceptor variant resulting in an alternate CHRNA4 transcript predicted to be targeted for nonsense-mediated decay, was associated with decreased CHRNA4 expression in physiologically normal human brains (lowest P=7.3 × 10 -4). Importantly, rs2273500-C was associated with increased lung cancer risk (N=28 998, odds ratio=1.06 and 95% confidence interval=1.00-1.12), likely through its effect on smoking, as rs2273500-C was no longer associated with lung cancer after adjustment for smoking. Using criteria for smoking behavior that encompass more than the single 'cigarettes per day' item, we identified a common CHRNA4 variant with important regulatory properties that contributes to nicotine dependence and smoking-related consequences.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

5.620

1.172