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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Optogenetic stimulation of neuronal repair.
Curr. Biol. 25, R1-R3 (2015)
Environmental insult, disease or trauma can affect the physical integrity of neuronal circuits, and the inability of many neurons to regenerate injured axons invariably leads to irreversible neural dysfunction [1]. The conserved second messenger cyclic adenosine monophosphate (cAMP) can promote axonal re-growth [2-5]. Widely used pharmacological or genetic approaches to increase intracellular levels of cAMP are often inadequate for precise neural-circuit reconstruction because their activity cannot be easily timed to specific target cells. These shortcomings have prevented the controlled repair of pre-defined neurons at selected time points in whole specimens. Thus, technologies to guide neuronal repair in time and space would enable studies of neural-circuit recovery with unprecedented resolution. Towards this aim, we have implemented a proof-of-principle optogenetic method to promote the selective regeneration of refractory axons in a living vertebrate.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0960-9822
e-ISSN
1879-0445
Zeitschrift
Current Biology
Quellenangaben
Band: 25,
Heft: 22,
Seiten: R1-R3
Verlag
Elsevier
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed