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Light fluence normalization in turbid tissues via temporally unmixed multispectral optoacoustic tomography.
Opt. Lett. 40, 4691-4694 (2015)
Discerning the accurate distribution of chromophores and biomarkers by means of optoacoustic imaging is commonly challenged by the highly heterogeneous excitation light patterns resulting from strong spatial variations of tissue scattering and absorption. Here we used the light-fluence dependent switching kinetics of reversibly switchable fluorescent proteins (RSFPs), in combination with real-time acquisition of volumetric multi-spectral optoacoustic data to correct for the light fluence distribution deep in scattering media. The new approach allows for dynamic fluence correction in time-resolved imaging, e.g., of moving organs, and can be extended to work with a large palette of available synthetic and genetically encoded photochromic substances for multiplexed wavelength-specific fluence normalization.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
2.110
2.110
22
25
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
englisch
Veröffentlichungsjahr
2015
HGF-Berichtsjahr
2015
ISSN (print) / ISBN
0146-9592
e-ISSN
1539-4794
Zeitschrift
Optics Letters
Quellenangaben
Band: 40,
Heft: 20,
Seiten: 4691-4694
Verlag
Optical Society of America (OSA)
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Biological and Medical Imaging (IBMI)
Institute of Developmental Genetics (IDG)
Institute of Developmental Genetics (IDG)
POF Topic(s)
30205 - Bioengineering and Digital Health
30505 - New Technologies for Biomedical Discoveries
30204 - Cell Programming and Repair
30505 - New Technologies for Biomedical Discoveries
30204 - Cell Programming and Repair
Forschungsfeld(er)
Enabling and Novel Technologies
Genetics and Epidemiology
Genetics and Epidemiology
PSP-Element(e)
G-505500-001
G-505590-001
G-552000-001
G-500500-001
G-505590-001
G-552000-001
G-500500-001
PubMed ID
26469596
WOS ID
WOS:000364468400031
Scopus ID
84959342700
Erfassungsdatum
2015-11-04