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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Neuropeptide S receptor gene variation differentially modulates fronto-limbic effective connectivity in childhood and adolescence.
Cereb. Cortex 27, 554-566 (2015)
The neuropeptide S (NPS) system contributes to the pathogenesis of anxiety. The more active T allele of the functional rs324981 variant in the neuropeptide S receptor gene (NPSR1) is associated with panic disorder (PD) and distorted cortico-limbic activity during emotion processing in healthy adults and PD patients. This study investigated the influence of NPSR1 genotype on fronto-limbic effective connectivity within the developing brain. Sixty healthy subjects (8-21 years) were examined using an emotional go-nogo task and fMRI. Fronto-limbic connectivity was determined using Dynamic Causal Modeling. In A allele carriers, connectivity between the right middle frontal gyrus (MFG) and the right amygdala was higher in older (≥14 years) than that in younger (<14 years) probands, whereas TT homozygotes ≥14 years showed a reduction of fronto-limbic connectivity between the MFG and both the amygdala and the insula. Fronto-limbic connectivity varied between NPSR1 genotypes in the developing brain suggesting a risk-increasing effect of the NPSR1T allele for anxiety-related traits via impaired top-down control of limbic structures emerging during adolescence. Provided robust replication in longitudinal studies, these findings may constitute valuable biomarkers for early targeted prevention of anxiety disorders.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Dcm ; Nps ; Npsr1 ; Anxiety ; Dynamic Causal Modeling; Social Anxiety Disorder; Functional Connectivity; Emotion Regulation; Panic Disorder; Generalized Anxiety; Facial Expressions; Pubertal Changes; Neural Activity; Amygdala; Cortex
ISSN (print) / ISBN
1047-3211
e-ISSN
1460-2199
Zeitschrift
Cerebral Cortex
Quellenangaben
Band: 27,
Heft: 1,
Seiten: 554-566
Verlag
Oxford University Press
Verlagsort
Cary
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Neurogenomics (ING)