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Gomes, E.R.* ; Brockow, K. ; Kuyucu, S.* ; Saretta, F.* ; Mori, F.* ; Blanca-Lopez, N.* ; Ott, H.* ; Atanaskovic-Markovic, M.* ; Kidon, M.* ; Caubet, J.C.* ; Terreehorst, I.*

Drug hypersensitivity in children: Report from the pediatric task force of the EAACI Drug Allergy Interest Group.

Allergy 71, 149-161 (2015)
Verlagsversion Postprint DOI PMC
Open Access Green
When questioned, about 10% of the parents report suspected hypersensitivity to at least one drug in their children. However, only a few of these reactions can be confirmed as allergic after a diagnostic workup. There is still a lack of knowledge on drug hypersensitivity epidemiology, clinical spectrum and appropriate diagnostic methods particularly in children. Meanwhile, the tools used for drug hypersensitivity management in adults are applied also for children. Whereas this appears generally acceptable, some aspects of drug hypersensitivity and management differ with age. Most reactions in children are still attributed to betalactams. Some manifestations, such as non-steroidal anti-inflammatory drug-associated angioedema and serum sickness-like reactions are more frequent among young patients as compared to adults. Risk factors such as viral infections are particularly frequent in children, making the diagnosis challenging. The practicability and validity of skin test and other diagnostic procedures need further assessment in children. This paper presents an up-to-date review on epidemiology, clinical spectrum, diagnostic tools and current management of drug hypersensitivity in children. A new general algorithm for the study of these reactions in children is proposed. Data are presented focusing on reported differences between pediatric and adult patients, also identifying unmet needs to be addressed in further research.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Children ; Drug Allergy ; Drug Hypersensitivity ; Task Force Report; Generalized Exanthematous Pustulosis; Beta-lactam Antibiotics; Nonsteroidal Antiinflammatory Drugs; Stevens-johnson Syndrome; Basophil Activation Test; Sickness-like Reactions; Toxic Epidermal Necrolysis; Negative Predictive-value; Serum Sickness; Contrast-media
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Zeitschrift Allergy
Quellenangaben Band: 71, Heft: 2, Seiten: 149-161 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)