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Eyerich, K.* ; Eyerich, S. ; Biedermann, T.*

The multi-modal immune pathogenesis of atopic eczema.

Trends Immunol. 36, 788–801 (2015)
Postprint DOI PMC
Open Access Green
Atopic eczema (AE) is one of the most common inflammatory diseases, often constituting a lifelong burden for afflicted individuals. Recent findings have provided new insights into the pathogenesis of AE, revealing contributions of genetics, skin microbiota, and both innate and adaptive immunity in disease onset and progression. We review these findings here, assembling contributing factors conceptually into four modules that can interact in various ways to ultimately lead to epidermal barrier impairment, unchecked type 2 immunity, and chronic disease. We present this modular framework as a basis for understanding the varied presentations of AE, and in this context we propose a diagnostic and therapeutic algorithm aimed at the precise stratification of AE patients and the implementation of individualized medicine in AE standard of care.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 1471-4906
e-ISSN 1471-4981
Zeitschrift Trends in Immunology
Quellenangaben Band: 36, Heft: 12, Seiten: 788–801 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)
POF Topic(s) 30202 - Environmental Health
30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er) Allergy
PSP-Element(e) G-505400-001
G-552600-001
PubMed ID 26602548
DOI 10.1016/j.it.2015.10.006
Erfassungsdatum 2015-12-07
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