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The Role of Pax6 in the nervous system during development and in adulthood: Master control regulator or modular function?
In: Transcription Factors in the Nervous System: Development, Brain Function, and Diseases. Weinheim: Wiley-VCH, 2006. 23-51
Different paired-box transcription factors control various aspects of cell fate during organ development. Here we focus on the paired-box transcription factor Pax6 that is mostly expressed in the developing forebrain including the eye, as well as the cerebellum and spinal cord and in adult neurogenic zones of the brain. In murine CNS development Pax6 acts as a key regulator of neurogenesis, proliferation and regionalization, with the former roles largely restricted to the developing forebrain. The differential use of the two DNA-binding domains of Pax6, the paired and the homeo domain, in the developing eye and telencephalon as well as differential splicing of the paired domain that allows regulating cell proliferation with or without an effect on neurogenesis, are further discussed. Thus, this overview highlights the molecular mechanisms accounting for the multitude of functions of Pax6 in the developing nervous system. © 2006 WILEY-VCH Verlag GmbH & Co. KGaA.
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Publikationstyp
Artikel: Sammelbandbeitrag/Buchkapitel
Herausgeber
Thiel, G.*
Schlagwörter
During Development ; Function Of Pax6 In Adult Brain ; In Adulthood ; Mechanisms Of Pax6 Function ; Molecular Features Of Pax6 ; Neural Development ; Role Of Pax6 In Nervous System ; Transcription Factors
ISBN
3-527-31285-4
Bandtitel
Transcription Factors in the Nervous System: Development, Brain Function, and Diseases
Quellenangaben
Seiten: 23-51
Verlag
Wiley-VCH
Verlagsort
Weinheim
Nichtpatentliteratur
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