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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
GPR17 expressing NG2-Glia: Oligodendrocyte progenitors serving as a reserve pool after injury.
Glia 64, 287-299 (2015)
In the adult brain NG2-glia continuously generate mature, myelinating oligodendrocytes. To which extent the differentiation process is common to all NG2-glia and whether distinct pools are recruited for repair under physiological and pathological conditions still needs clarification. Here, we aimed at investigating the differentiation potential of adult NG2-glia that specifically express the G-protein coupled receptor 17 (GPR17), a membrane receptor that regulates the differentiation of these cells at postnatal stages. To this aim, we generated the first BAC transgenic GPR17-iCreERT2 mouse line for fate mapping studies. In these mice, under physiological conditions, GPR17+ cells -in contrast to GPR17- NG2-glia- did not differentiate within 3 months, a peculiarity that was overcome after cerebral damage induced by acute injury or ischemia. After these insults, GPR17+ NG2-glia rapidly reacted to the damage and underwent maturation, suggesting that they represent a 'reserve pool' of adult progenitors maintained for repair purposes.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Differentiation ; Ischemia ; Oligodendrocyte Progenitors ; Oligodendrogenesis ; Repair
ISSN (print) / ISBN
0894-1491
e-ISSN
1098-1136
Zeitschrift
Glia
Quellenangaben
Band: 64,
Heft: 2,
Seiten: 287-299
Verlag
Wiley
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Stem Cell Research (ISF)