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Telieps, T. ; Köhler, M. ; Treise, I. ; Förtsch, K. ; Adler, T. ; Busch, D.H.* ; Hrabě de Angelis, M. ; Verschoor, A.* ; Adler, K. ; Bonifacio, E. ; Ziegler, A.-G.

Longitudinal frequencies of blood leukocyte sub-populations differ between NOD and NOR mice, but do not predict diabetes in NOD mice.

J. Diabetes Res. 2016:4208156 (2016)

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© 2016 Tanja Telieps et al. Immune phenotyping provides insight into disease pathogenesis and prognostic markers. Trajectories from age of 4 to 36 weeks were modeled for insulin autoantibodies and for leukocyte subpopulations in peripheral blood from female NOD (n = 58) and NOR (n = 22) mice. NOD mice had higher trajectories of insulin autoantibodies, CD4+ and CD8+ T lymphocytes, B lymphocytes, IgD+IgM- B lymphocytes, and NK cells and lower trajectories of CD4+CD25+ T lymphocytes, IgM+ B lymphocytes, granulocytes, and monocytes than NOR mice (all p < 0.001). Of these, only the increased IAA trajectory was observed in NOD mice that developed diabetes as compared to NOD mice that remained diabetes-free. Therefore, the profound differences in peripheral blood leukocyte proportions observed between the diabetes-prone NOD mice and the diabetes-resistant mice do not explain the variation in diabetes development within NOD mice and do not provide markers for diabetes prediction in this model.

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