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Wu, J.I.* ; Rajendra, R. ; Barsi, J.C.* ; Durfee, L.* ; Benito, E . * ; Gao, G.* ; Kuruvilla, M.* ; Hrdlicková, R.* ; Liss, A.S.* ; Artzt, K.*

Targeted disruption of Mib2 causes exencephaly with a variable penetrance.

Genesis 45, 722-727 (2007)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Mib1 and Mib2 ubiquitin ligases are very similar in their domain construction. They partake in the Notch signaling pathway by ubiquitinating the Notch receptors Delta and Jagged prior to endocytosis. We have created a targeted mutation of Mib2 and show that its phenotype is a variable penetrance, failure to close the cranial neural tube. The penetrance depends on the genetic background but it appears that Mib2 is not completely essential in mouse development.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Mib2; exencephaly; neural tube closure; MMU4; ubiquitin ligase
ISSN (print) / ISBN 1526-954X
e-ISSN 1526-968X
Zeitschrift Genesis : The Journal of Genetics and Development
Quellenangaben Band: 45, Heft: 11, Seiten: 722-727 Artikelnummer: , Supplement: ,
Verlag Wiley
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)