Startseite
English
Erweiterte Suche
Durchblättern nach ...
Publikationen im Überblick
Ansprechpartner
Hilfe
DOI
PMC
 |
|
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Regulated necrosis: Disease relevance and therapeutic opportunities.
Nat. Rev. Drug Discov. 15, 348-366 (2016)
The discovery of regulated cell death presents tantalizing possibilities for gaining control over the life-death decisions made by cells in disease. Although apoptosis has been the focus of drug discovery for many years, recent research has identified regulatory mechanisms and signalling pathways for previously unrecognized, regulated necrotic cell death routines. Distinct critical nodes have been characterized for some of these alternative cell death routines, whereas other cell death routines are just beginning to be unravelled. In this Review, we describe forms of regulated necrotic cell death, including necroptosis, the emerging cell death modality of ferroptosis (and the related oxytosis) and the less well comprehended parthanatos and cyclophilin D-mediated necrosis. We focus on small molecules, proteins and pathways that can induce and inhibit these non-apoptotic forms of cell death, and discuss strategies for translating this understanding into new therapeutics for certain disease contexts.
Altmetric
Weitere Metriken?
Zusatzinfos bearbeiten
[➜Einloggen]
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Mitochondrial Permeability Transition; Glutathione-peroxidase 4; Nonapoptotic Cell-death; Mixed Lineage Kinase; Small-molecule Inhibitor; Domain-like Protein; Nlrp3 Inflammasome Activation; Alpha-dependent Apoptosis; Transient Focal Ischemia; Kappa-b Activation
ISSN (print) / ISBN
1474-1776
Zeitschrift
Nature Reviews - Drug Discovery
Quellenangaben
Band: 15,
Heft: 5,
Seiten: 348-366
Verlag
Nature Publishing Group
Verlagsort
London
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Developmental Genetics (IDG)