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Biological monitoring of welders exposed to aluminium.
Toxicol. Lett. 162, 239-245 (2006)
To evaluate an adequate strategy for biological monitoring of aluminium (Al), a group of 62 Al welders (age in 1999: 23-51 years, median 35 years) was surveyed annually from 1999 to 2003 by determination of pre- and post-shift Al in urine and plasma. Biomonitoring was supplemented by personal air measurements of the total dust concentration. The welders' internal exposure was compared to the exposure of 60 non-exposed assembly workers (age in 1999: 21-51 years, median: 36 years) who were surveyed in 1999, 2001 and 2003. Having a nearly constant dust exposure, median concentrations of Al in urine (Al in plasma) of the welders decreased from 40.1 μg/g to 19.8 μg/g creatinine (8.7 to 4.6 μg/l). For the control group the median levels of Al in urine (plasma) ranged from 4.8 μg/g to 5.2 μg/g creatinine (2.4-4.3 μg/l) indicating a higher sensitivity for the marker Al in urine. No systematic differences have been found between pre- and post-shift internal exposure. This might be caused by the slow elimination kinetics and low systemic bioavailability of Al. A correlation analysis did not yield close relationships between dust exposure, Al in plasma and Al in urine underlining the importance of biomonitoring for assessment of Al exposure. © 2005 Elsevier Ireland Ltd. All rights reserved.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
aluminium; aluminium welders; biomonitoring; welding fumes
ISSN (print) / ISBN
0378-4274
e-ISSN
1879-3169
Zeitschrift
Toxicology Letters
Quellenangaben
Band: 162,
Heft: 2-3,
Seiten: 239-245
Verlag
Elsevier
Verlagsort
Amsterdam
Begutachtungsstatus
Peer reviewed