PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Thomas, D.M.* ; Wilhelm, M.* ; Cleton-Jansen, A.M.* ; Dirksen, U.* ; Entz-Werlé, N.* ; Gelderblom, H.* ; Hassan, B.* ; Jürgens, H.* ; Koster, J.* ; Kovar, H.* ; Lankester, A.C.* ; Lewis, I.J.* ; Myklebost, O.* ; Nathrath, M. ; Picci, P.* ; Whelan, J.S.* ; Hogendoorn, P.C.W.* ; Bielack, S.S.*

Workshop report on the European Bone Sarcoma Networking Meeting: Integration of clinical trials with tumor biology.

J. Adolesc.Young Adult Oncol. 1, 118-123 (2011)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
A key workshop was held in The Netherlands in June 2011, hosted by several European bone sarcoma networks and with a broad range of stakeholders from Europe and Australia. The purpose of the meeting was to identify the strengths and weaknesses in current clinical trials for bone sarcomas and to make recommendations as to how to accelerate progress in this field. Two areas of particular interest were discussed. First, all participants agreed upon the importance of tumor biology to understanding clinical responses for all types of bone sarcoma. Various barriers to biobanking tumor and germline specimens were canvassed and are outlined in this paper. Second, there was consideration of the particular challenges of dealing with adolescent and young adult cancers, exemplified by bone sarcomas. Participants recommended greater engagement of both pediatric and adult sarcoma trial organizations to address this issue. Specific opportunities were identified to develop biological sub-studies within osteosarcoma, focused on understanding germ line risk and pharmacogenomics defining toxicity and biological responses. In Ewing sarcoma, it was harder to define opportunities for biological insights. There was agreement that the results for insulin-like growth factor pathway inhibition in Ewing family tumors were disappointing, but represented a clear indication of the need for companion biologic studies to develop predictive biomarkers. The meeting ended with broad commitment to working together to make progress in this rare but important subgroup of cancers.
Impact Factor
Scopus SNIP
Altmetric
0.000
0.000
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2011
HGF-Berichtsjahr 0
ISSN (print) / ISBN 2156-5333
e-ISSN 2156-535X
Zeitschrift Journal of Adolescent and Young Adult Oncology
Quellenangaben Band: 1, Heft: 3, Seiten: 118-123 Artikelnummer: , Supplement: ,
Verlag Mary Ann Liebert
Verlagsort New Rochelle, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pathology (PATH)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-500300-001
PubMed ID 26811922
DOI 10.1089/jayao.2012.0005
Erfassungsdatum 2011-12-31
[➜Korrektur melden]