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Olivieri, M.* ; Heinrich, J. ; Schlünssen, V.* ; Antò, J.M.* ; Forsberg, B.* ; Janson, C.* ; Leynaert, B.* ; Norbäck, D.* ; Sigsgaard, T.* ; Svanes, C.* ; Tischer, C.G. ; Villani, S.* ; Jarvis, D.* ; Verlato, G.* ; European Community Respiratory Health Survey II (*)

The risk of respiratory symptoms on allergen exposure increases with increasing specific IgE levels.

Allergy 71, 859-868 (2016)
Verlagsversion DOI PMC
Free by publisher
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
BACKGROUND: The relation between IgE sensitization and allergic respiratory symptoms has usually been evaluated by dichotomizing specific IgE levels. The aim of the present study was to evaluate the association between specific IgE levels and risk of symptoms on allergen-related exposure, with special reference to allergen-related asthma-rhinitis comorbidity. METHODS: We considered 6391 subjects enrolled within the European Community Respiratory Health Survey 2, having information on cat/grass/D. pteronissinus IgE levels and symptoms on exposure to animals/pollen/dust. The risk of oculonasal/asthmalike/both symptoms was evaluated by a multinomial logistic model. RESULTS: A clear positive association was observed between specific IgE levels to cat/grass/mite and the risk of symptoms on each allergen-related exposure (test for trend with p<0.001). This trend was particularly pronounced when considering the coexistence of asthma-like and oculonasal symptoms. Compared to not-sensitized subjects, subjects with specific IgE to cat >=3.5 kU/l presented Relative Risk Ratios of 11.4 (95% CI 6.7-19.2), 18.8 (8.2-42.8), and 55.3 (30.5-100.2) when considering respectively, only oculonasal symptoms, only asthmalike symptoms, or both. A similar pattern was observed when considering specific IgE to grass/mite and symptoms on exposure to pollen/dust. Also the proportion of people using inhaled medicines or visiting a general practitioner for breathing problems in the previous year increased with increasing sum of specific IgE to cat/grass/mite. CONCLUSION: Specific IgE levels are the most important predictor of allergen-related symptoms. The risk of both oculonasal/asthmalike symptoms increases with specific IgE levels, suggesting that specific IgE contribute to the "united airways disease".
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Allergen Exposure ; Allergic Respiratory Symptoms ; Specific Ige Levels ; United Airways Disease; Inhalant Allergens; Asthma Morbidity; Health-survey; Sensitization; Adults; Children; Cohort; Rhinitis; Smoking; Cat
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Zeitschrift Allergy
Quellenangaben Band: 71, Heft: 6, Seiten: 859-868 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)