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Insulin target tissues and cells.
In: Drug Discovery and Evaluation: Pharmacological Assays. Cham, Switzerland: Springer, 2016. 2681-2722
Rodent adipose tissue and cells represent the targets exhibiting the most prominent insulin sensitivity (i.e., lowest EC/IC50) and responsiveness (i.e., highest fold stimulation/inhibition above basal) of the relevant insulin signaling cascades (e.g., insulin receptor activation) and metabolic end effector systems (e.g., lipolysis) in comparison to liver (e.g., gluconeogenesis) and muscle cells (e.g., glucose transport). This might be based in part on technical advantages of the adipose tissue/adipocyte preparation in comparison to that of muscle/myocytes. But more likely, it reflects the exquisite physiological role of the adipose tissue in the regulation and coordination of glucose and lipid metabolism, i.e., insulin stimulation of lipid synthesis (lipogenesis) and insulin inhibition of lipolysis. On the basis of their relatively easy technical preparation, functional adipose tissue fragments (epididymal fat pads) and primary adipocytes (isolated epididymal adipocytes) from rats as well as adipocyte cell lines derived from mice (3T3-L1, F442A) are the first choice for the development of robust and reliable cell-/tissue-based assay systems for insulin-like activity.
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Publikationstyp
Artikel: Sammelbandbeitrag/Buchkapitel
Herausgeber
Hock, F.J.*
Sprache
englisch
Veröffentlichungsjahr
2016
HGF-Berichtsjahr
0
e-ISSN
978-3-319-05392-9
ISBN
978-3-319-05391-2
Bandtitel
Drug Discovery and Evaluation: Pharmacological Assays
Quellenangaben
Seiten: 2681-2722
Verlag
Springer
Verlagsort
Cham, Switzerland
Institut(e)
Institute of Diabetes and Obesity (IDO)
POF Topic(s)
30201 - Metabolic Health
Forschungsfeld(er)
Helmholtz Diabetes Center
PSP-Element(e)
G-502200-001
Scopus ID
84957634867
Erfassungsdatum
2016-02-20