möglich sobald bei der ZB eingereicht worden ist.
Measurement of glucose absorption.
In: Drug Discovery and Evaluation: Pharmacological Assays. Cham, Switzerland: Springer, 2016. 3059-3070
Starch as the predominant ingredient of human food is rapidly degraded in the gastrointestinal tract by salivary and pancreatic α-amylase to maltose which is further hydrolyzed by maltase localized in the brush border of the small intestine to glucose. Glucose is immediately absorbed leading to hyperglycemia and consequently to hyperinsulinemia. Both phenomena are undesirable in diabetics and in obese patients. The inhibition of the digestion of starch leads to a decrease and a retardation of glucose absorption. In nature, α-amylase inhibitors are found in wheat and other grains (Shainkin and Birk 1970). Several inhibitors of amylase and α-glucosidase have been developed (Bischoff 1991). Animal experiments with high doses of absorbable α-glucosidase inhibitors indicate that lysosomal storage of glycogen may occur (Lembcke et al. 1991).
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Publikationstyp
Artikel: Sammelbandbeitrag/Buchkapitel
Herausgeber
Hock, F.J.*
Sprache
englisch
Veröffentlichungsjahr
2016
HGF-Berichtsjahr
2016
e-ISSN
978-3-319-05392-9
ISBN
978-3-319-05391-2
Bandtitel
Drug Discovery and Evaluation: Pharmacological Assays
Quellenangaben
Seiten: 3059-3070
Verlag
Springer
Verlagsort
Cham, Switzerland
Institut(e)
Institute of Diabetes and Obesity (IDO)
POF Topic(s)
30201 - Metabolic Health
Forschungsfeld(er)
Helmholtz Diabetes Center
PSP-Element(e)
G-502200-001
Scopus ID
84957703567
Erfassungsdatum
2016-02-20