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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
A cybrid cell model for the assessment of the link between mitochondrial deficits and sporadic Parkinson's disease.
Methods Mol. Biol. 1265, 415-424 (2015)
Parkinson's disease (PD) is a multifactorial and clinically complex age-related movement disorder. The cause of its most common form (sporadic PD, sPD) is unknown, but one prominent causal factor is mitochondrial dysfunction. Although several genetic- and toxin-based models have been developed along the last decades to mimic the pathological cascade of PD, cellular models that reliably recapitulate the pathological features of the neurons that degenerate in PD are scarce. We describe here the generation of cytoplasmic hybrid cells (or cybrids) as a cellular model of sPD. This approach consists on the fusion of platelets harboring mtDNA from sPD patients with cells in which the endogenous mtDNA has been depleted (Rho0 cells). The sPD cybrid model has been successful in recapitulating most of the hallmarks of sPD, constituting now a validated model for addressing the link between mitochondrial dysfunction and sPD pathology.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Alpha-synuclein Oligomers ; Cellular Models ; Cybrids ; Mitochondria ; Mitochondrial Impairment ; Mtdna ; Neurodegeneration ; Oxidative Stress ; Parkinson's Disease ; Rho Cells
ISSN (print) / ISBN
1064-3745
e-ISSN
1940-6029
Konferenztitel
Mitochondrial Medicine
Zeitschrift
Methods in Molecular Biology
Quellenangaben
Band: 1265,
Seiten: 415-424
Verlag
Springer
Verlagsort
Berlin [u.a.]
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Diabetes and Obesity (IDO)