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Nati, M.* ; Haddad, D.* ; Birkenfeld, A.L. ; Koch, C.A.* ; Chavakis, T. ; Chatzigeorgiou, A.

The role of immune cells in metabolism-related liver inflammation and development of Non-Alcoholic Steatohepatitis (NASH).

Rev. Endocr. Metab. Disord. 17, 29-39 (2016)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The low grade inflammatory state present in obesity promotes the progression of Non-Alcoholic Fatty Liver Disease (NAFLD). In Non-Alcoholic Steatohepatitis (NASH), augmented hepatic steatosis is accompanied by aberrant intrahepatic inflammation and exacerbated hepatocellular injury. NASH is an important disorder and can lead to fibrosis, cirrhosis and even neoplasia. The pathology of NASH involves a complex network of mechanisms, including increased infiltration of different subsets of immune cells, such as monocytes, T-lymphocytes and neutrophils, to the liver, as well as activation and in situ expansion of liver resident cells such as Kupffer cells or stellate cells. In this review, we summarize recent advances regarding understanding the role of the various cells of the innate and adaptive immunity in NASH development and progression, and discuss possible future therapeutic options and tools to interfere with disease progression.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Hepatic Stellate Cells (hsc) ; Kupffer Cells ; Non-alcoholic Steatohepatitis (nash) ; Obesity ; Steatosis ; T-regulatory Cells (tregs); Hepatic Stellate Cells; Regulatory T-cells; Adipose-tissue Inflammation; Diet-induced Obesity; Activation In-vivo; Collagen Type-i; High-fat Diet; Insulin-resistance; Kupffer Cells; Dendritic Cells
Sprache englisch
Veröffentlichungsjahr 2016
HGF-Berichtsjahr 2016
ISSN (print) / ISBN 1389-9155
e-ISSN 1573-2606
Zeitschrift Reviews in Endocrine & Metabolic Disorders
Quellenangaben Band: 17, Heft: 1, Seiten: 29-39 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Boston
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502600-008
G-502600-012
G-502600-001
DOI 10.1007/s11154-016-9339-2
WOS ID WOS:000376887800004
PubMed ID 26847547
Erfassungsdatum 2016-03-07
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