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Nat. Genet. 48, 497-499 (2016)
There is considerable controversy regarding epigenetic inheritance in mammalian gametes. Using in vitro fertilization to ensure exclusive inheritance via the gametes, we show that a parental high-fat diet renders offspring more susceptible to developing obesity and diabetes in a sex- and parent of origin-specific mode. The epigenetic inheritance of acquired metabolic disorders may contribute to the current obesity and diabetes pandemic.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
31.616
6.234
175
217
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Body-mass Index; High-fat Diet; Maternal Obesity; Programs; Contribute; Mammals; Alters; Mice
Sprache
englisch
Veröffentlichungsjahr
2016
HGF-Berichtsjahr
2016
ISSN (print) / ISBN
1061-4036
e-ISSN
1546-1718
Zeitschrift
Nature Genetics
Quellenangaben
Band: 48,
Heft: 5,
Seiten: 497-499
Verlag
Nature Publishing Group
Verlagsort
New York, NY
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Experimental Genetics (IEG)
Institute of Computational Biology (ICB)
Institute of Diabetes and Obesity (IDO)
Institute of Computational Biology (ICB)
Institute of Diabetes and Obesity (IDO)
POF Topic(s)
30201 - Metabolic Health
30502 - Diabetes: Pathophysiology, Prevention and Therapy
90000 - German Center for Diabetes Research
30205 - Bioengineering and Digital Health
30502 - Diabetes: Pathophysiology, Prevention and Therapy
90000 - German Center for Diabetes Research
30205 - Bioengineering and Digital Health
Forschungsfeld(er)
Genetics and Epidemiology
Enabling and Novel Technologies
Helmholtz Diabetes Center
Enabling and Novel Technologies
Helmholtz Diabetes Center
PSP-Element(e)
G-500600-004
G-500600-001
G-500600-005
G-500600-006
G-501900-062
G-501900-063
G-501900-064
G-503800-001
G-502200-001
G-500600-001
G-500600-005
G-500600-006
G-501900-062
G-501900-063
G-501900-064
G-503800-001
G-502200-001
DOI
10.1038/ng.3527
WOS ID
WOS:000374834100007
Scopus ID
84961226127
PubMed ID
26974008
Erfassungsdatum
2016-03-16