PuSH - Publikationsserver des Helmholtz Zentrums München

Larsson, H.E.* ; Vehik, K.* ; Haller, M.J.* ; Liu, X.* ; Akolkar, B.* ; Hagopian, W.* ; Krischer, J.* ; Lernmark, A.* ; She, J.X.* ; Simell, O.* ; Toppari, J.* ; Ziegler, A.-G. ; Rewers, M.* ; TEDDY Study Group (Beyerlein, A. ; Hummel, M. ; Hummel, S. ; Knopff, A. ; Peplow, C. ; Roth, R. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.)

Growth and risk for islet autoimmunity and progression to type 1 diabetes in early childhood: The Environmental Determinants of Diabetes in the Young Study.

Diabetes 65, 1988-1995 (2016)
Verlagsversion Postprint DOI PMC
Open Access Green
Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This study explored the relationship between weight, height and development of persistent islet autoimmunity and progression to type 1 diabetes during the first 4 years of life in 7,468 children at genetic risk of type 1 diabetes, followed in Finland, Germany, Sweden and US. Growth data collected every third month were used to estimate individual growth curves using mixed models. Cox proportional hazards models were used to evaluate the body size and risk of islet autoimmunity and T1D. In the overall cohort, development of islet autoimmunity (n=575) was related to weight z-scores at 12 months, (HR 1.16 per 1.14 kg in males or per 1.02 kg in females; 95%CI 1.06-1.27, p<0.001, FDR=0.008), but not at 24 or 36 months. A similar relationship was seen between weight z-scores and development of multiple islet autoantibodies (1 year, HR 1.21 95%CI 1.08-1.35, p=0.001, FDR=0.008; 2 years, HR 1.18 95% CI 1.06-1.32, p=0.004, FDR=0.02). No association was found between weight or height and type 1 diabetes (n=169). In conclusion, greater weight in the first years of life was associated with an increased risk of development of islet autoimmunity.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Increased Linear Growth; Body-mass Index; Birth-weight; Insulin-resistance; Accelerator Hypothesis; General-population; Affected Children; Hla Genotypes; Infant Growth; Age
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Zeitschrift Diabetes
Quellenangaben Band: 65, Heft: 7, Seiten: 1988-1995 Artikelnummer: , Supplement: ,
Verlag American Diabetes Association
Verlagsort Alexandria, VA.
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research Type 1 (IDF)