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Epigenetics reloaded: The single-cell revolution.
Trends Cell Biol. 24, 712-723 (2014)
Mechanistically, how epigenetic states are inherited through cellular divisions remains an important open question in the chromatin field and beyond. Defining the heritability of epigenetic states and the underlying chromatin-based mechanisms within a population of cells is complicated due to cell heterogeneity combined with varying levels of stability of these states; thus, efforts must be focused toward single-cell analyses. The approaches presented here constitute the forefront of epigenetics research at the single-cell level using classic and innovative methods to dissect epigenetics mechanisms from the limited material available in a single cell. This review further outlines exciting future avenues of research to address the significance of epigenetic heterogeneity and the contributions of microfluidics technologies to single-cell isolation and analysis.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Epigenetics ; Epigenomics ; Live Cell ; Microfluidics ; Single Cell
ISSN (print) / ISBN
0962-8924
e-ISSN
1879-3088
Zeitschrift
Trends in Cell Biology
Quellenangaben
Band: 24,
Heft: 11,
Seiten: 712-723
Verlag
Elsevier
Verlagsort
Cambridge
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Functional Epigenetics (IFE)