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Unsafe SETs: Histone lysine methyltransferases and cancer.
Trends Biochem. Sci. 27, 396-402 (2002)
Enzymes that covalently modify histones control many cellular processes by affecting gene expression. A new class of these enzymes is the histone lysine methyltransferase family, whose catalytic activity lies within a conserved domain, the SET domain. This article surveys the evidence for a connection between SET-domain-containing proteins and cancer. It proposes that deregulation of SET-domain function has an important role in carcinogenesis.
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Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
englisch
Veröffentlichungsjahr
2002
HGF-Berichtsjahr
0
ISSN (print) / ISBN
0376-5067
e-ISSN
0968-0004
Zeitschrift
Trends in Biochemical Sciences : TIBS
Quellenangaben
Band: 27,
Heft: 8,
Seiten: 396-402
Verlag
Elsevier
Verlagsort
Cambridge
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Functional Epigenetics (IFE)
POF Topic(s)
30203 - Molecular Targets and Therapies
Forschungsfeld(er)
Helmholtz Diabetes Center
PSP-Element(e)
G-502800-001
PubMed ID
12151224
Erfassungsdatum
2002-12-31