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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
How cells build totipotency and pluripotency: Nuclear, chromatin and transcriptional architecture.
Curr. Opin. Cell Biol. 34, 9-15 (2015)
Totipotent and pluripotent cells display different degrees of cellular plasticity. After fertilization, embryonic cells transit naturally from a totipotent to a pluripotent state. Major changes in nuclear architecture, chromatin mobility and gene expression occur during this transition. In particular, nuclear architecture has recently emerged as a potential regulator of heterochromatin formation in the early embryo. Future research should address whether a causal, functional link between nuclear organization and gene regulation is a general theme during reprogramming and the formation of pluripotent cells.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0955-0674
e-ISSN
1879-0410
Zeitschrift
Current Opinion in Cell Biology
Quellenangaben
Band: 34,
Seiten: 9-15
Verlag
Elsevier
Verlagsort
Kidlington
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Epigenetics and Stem Cells (IES)