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Weinandy, F. ; Ninkovic, J. ; Götz, M.

Restrictions in time and space - new insights into generation of specific neuronal subtypes in the adult mammalian brain.

Eur. J. Neurosci. 33, 1045-1054 (2011)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Key questions in regard to neuronal repair strategies are which cells are best suited to regenerate specific neuronal subtypes and how much of a neuronal circuit needs to persist in order to allow its functional repair. Here we discuss recent findings in the field of adult neurogenesis, which shed new light on these questions. Neural stem cells in the adult brain generate very distinct types of neurons depending on their regional and temporal specification. Moreover, distinct brain regions differ in the mode of neuron addition in adult neurogenesis, suggesting that different brain circuits may be able to cope differently with the incorporation of new neurons. These new insights are then considered in regard to the choice of cells with the appropriate region-specific identity for repair strategies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter neural stem cells; neurogenesis; neuronal repair; neuronal subtype specification; olfactory bulk; transcription factors
ISSN (print) / ISBN 0953-816X
e-ISSN 1460-9568
Zeitschrift European Journal of Neuroscience
Quellenangaben Band: 33, Heft: 6, Seiten: 1045-1054 Artikelnummer: , Supplement: ,
Verlag Wiley
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)