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Restrictions in time and space - new insights into generation of specific neuronal subtypes in the adult mammalian brain.
Eur. J. Neurosci. 33, 1045-1054 (2011)
Key questions in regard to neuronal repair strategies are which cells are best suited to regenerate specific neuronal subtypes and how much of a neuronal circuit needs to persist in order to allow its functional repair. Here we discuss recent findings in the field of adult neurogenesis, which shed new light on these questions. Neural stem cells in the adult brain generate very distinct types of neurons depending on their regional and temporal specification. Moreover, distinct brain regions differ in the mode of neuron addition in adult neurogenesis, suggesting that different brain circuits may be able to cope differently with the incorporation of new neurons. These new insights are then considered in regard to the choice of cells with the appropriate region-specific identity for repair strategies.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
3.658
1.004
21
29
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
neural stem cells; neurogenesis; neuronal repair; neuronal subtype specification; olfactory bulk; transcription factors
Sprache
englisch
Veröffentlichungsjahr
2011
HGF-Berichtsjahr
2011
ISSN (print) / ISBN
0953-816X
e-ISSN
1460-9568
Zeitschrift
European Journal of Neuroscience
Quellenangaben
Band: 33,
Heft: 6,
Seiten: 1045-1054
Verlag
Wiley
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Stem Cell Research (ISF)
POF Topic(s)
30204 - Cell Programming and Repair
Forschungsfeld(er)
Stem Cell and Neuroscience
PSP-Element(e)
G-500800-001
PubMed ID
21395847
Scopus ID
79952583391
Erfassungsdatum
2011-07-19