PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Bošković, A.* ; Torres-Padilla, M.E.*

Histone variants and reprogramming in early development.

In: Epigenetics and Human Health. Heidelberg: Springer, 2015. 43-68 ( ; 4)
DOI
In addition to the well-studied epigenetic mechanisms associated with DNA methylation and histone modifications, histone variants have emerged as major regulators of chromatin activity. Apart from the major core histones, whose synthesis and incorporation into chromatin is linked to the S-phase of the cell cycle, histone ‘variants’ are synthesised and incorporated into chromatin independently of DNA synthesis. These replacement histones confer distinct properties to nucleosomes and appear to be involved in important epigenetic processes. A significant role for histone variants in specialised chromatin signatures after fertilisation has emerged in the recent years. Here we review our knowledge on the involvement and the function of histone variants during the reprogramming phase occurring after mammalian fertilisation in vivo. We postulate that addressing the reprogramming mechanisms in its natural context, where this process occurs with a high efficiency to give rise to a new developmental programme, will help us to understand how we can modulate cell plasticity in induced and experimental models. Although there is still much to learn on how specific histone variants regulate reprogramming mechanistically, histone variants provide a remarkably versatile and exquisitely powerful way of regulating chromatin function in different biological contexts. Thus, the usage of histone variants provides an extra layer of regulation to the complexity of the reprogramming process.
Scopus
Cited By
Altmetric
1
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Sammelbandbeitrag/Buchkapitel
Herausgeber Walter, J.* ; Meissner, A.*
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2014
ISSN (print) / ISBN 2191-2262
e-ISSN 2191-2270
Bandtitel Epigenetics and Human Health
Quellenangaben Band: 4, Heft: , Seiten: 43-68 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Heidelberg
Institut(e) Institute of Epigenetics and Stem Cells (IES)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-506200-001
DOI 10.1007/978-3-642-31974-7_3
Scopus ID 84921791191
Erfassungsdatum 2014-12-31
[➜Korrektur melden]