PuSH - Publikationsserver des Helmholtz Zentrums München: Histone variants and reprogramming in early development.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Bošković, A.* ; Torres-Padilla, M.E.*

Histone variants and reprogramming in early development.

In: Epigenetics and Human Health. Heidelberg: Springer, 2015. 43-68 ( ; 4)

DOI

Abstract
Metriken
Zusatzinfos

In addition to the well-studied epigenetic mechanisms associated with DNA methylation and histone modifications, histone variants have emerged as major regulators of chromatin activity. Apart from the major core histones, whose synthesis and incorporation into chromatin is linked to the S-phase of the cell cycle, histone ‘variants’ are synthesised and incorporated into chromatin independently of DNA synthesis. These replacement histones confer distinct properties to nucleosomes and appear to be involved in important epigenetic processes. A significant role for histone variants in specialised chromatin signatures after fertilisation has emerged in the recent years. Here we review our knowledge on the involvement and the function of histone variants during the reprogramming phase occurring after mammalian fertilisation in vivo. We postulate that addressing the reprogramming mechanisms in its natural context, where this process occurs with a high efficiency to give rise to a new developmental programme, will help us to understand how we can modulate cell plasticity in induced and experimental models. Although there is still much to learn on how specific histone variants regulate reprogramming mechanistically, histone variants provide a remarkably versatile and exquisitely powerful way of regulating chromatin function in different biological contexts. Thus, the usage of histone variants provides an extra layer of regulation to the complexity of the reprogramming process.

Scopus
Cited By

Altmetric