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Gomes, I.* ; Bobeck, E.N.* ; Margolis, E.B.* ; Gupta, A.* ; Sierra, S.* ; Fakira, A.K.* ; Fujita, W.* ; Müller, T.D. ; Müller, A.* ; Tschöp, M.H. ; Kleinau, G.* ; Fricker, L.D.* ; Devi, L.A.*

Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.

Sci. Signal. 9:ra43 (2016)
Verlagsversion Postprint DOI PMC
Open Access Green
PEN is an abundant peptide in the brain that has been implicated in the regulation of feeding. We identified a receptor for PEN in mouse hypothalamus and Neuro2A cells. PEN bound to and activated GPR83, a G protein (heterotrimeric guanine nucleotide)-binding protein)-coupled receptor (GPCR). Reduction of GPR83 expression in mouse brain and Neuro2A cells reduced PEN binding and signaling, consistent with GPR83 functioning as the major receptor for PEN. In some brain regions, GPR83 colocalized with GPR171, a GPCR that binds the neuropeptide bigLEN, another neuropeptide that is involved in feeding and is generated from the same precursor protein as is PEN. Coexpression of these two receptors in cell lines altered the signaling properties of each receptor, suggesting a functional interaction. Our data established PEN as a neuropeptide that binds GPR83 and suggested that these two ligand-receptor systems-PEN-GPR83 and bigLEN-GPR171-may be functionally coupled in the regulation of feeding.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Protein-coupled Receptor; Glucocorticoid-induced Receptor; Regulatory T-cells; Jp05 Messenger-rna; Mouse-brain; Rat-brain; In-vivo; Expression; Prosaas; Mice
Sprache englisch
Veröffentlichungsjahr 2016
HGF-Berichtsjahr 2016
ISSN (print) / ISBN 1945-0877
e-ISSN 1937-9145
Zeitschrift Science Signaling
Quellenangaben Band: 9, Heft: 425, Seiten: , Artikelnummer: ra43 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort Washington
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 30201 - Metabolic Health
90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502200-001
G-501900-221
DOI 10.1126/scisignal.aad0694
WOS ID WOS:000374829200004
Scopus ID 84964787407
PubMed ID 27117253
Erfassungsdatum 2016-05-09
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