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A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels.
Nat. Commun. 7:11812 (2016)
The outer subventricular zone (OSVZ) is a germinal layer playing key roles in the development of the neocortex, with particular relevance in gyrencephalic species such as human and ferret, where it contains abundant basal radial glia cells (bRGCs) that promote cortical expansion. Here we identify a brief period in ferret embryonic development when apical RGCs generate a burst of bRGCs that become founders of the OSVZ. After this period, bRGCs in the OSVZ proliferate and self-renew exclusively locally, thereby forming a self-sustained lineage independent from the other germinal layers. The time window for the brief period of OSVZ bRGC production is delineated by the coincident downregulation of Cdh1 and Trnp1, and their upregulation reduces bRGC production and prevents OSVZ seeding. This mechanism in cortical development may have key relevance in brain evolution and disease.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
11.329
2.922
61
63
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Mammalian Cerebral-cortex; Radial Glia; In-vivo; Human Neocortex; Spindle Orientation; Progenitor Cells; Visual-cortex; Lissencephalic Primate; Cortical Neurogenesis; Embryonic Neocortex
Sprache
Veröffentlichungsjahr
2016
HGF-Berichtsjahr
2016
ISSN (print) / ISBN
2041-1723
e-ISSN
2041-1723
Zeitschrift
Nature Communications
Quellenangaben
Band: 7,
Artikelnummer: 11812
Verlag
Nature Publishing Group
Verlagsort
London
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Stem Cell Research (ISF)
POF Topic(s)
30204 - Cell Programming and Repair
Forschungsfeld(er)
Stem Cell and Neuroscience
PSP-Element(e)
G-500800-001
WOS ID
WOS:000377385400001
Scopus ID
84973364635
Erfassungsdatum
2016-06-29