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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Histone H3 globular domain acetylation identifies a new class of enhancers.
Nat. Genet. 48, 681-686 (2016)
Histone acetylation is generally associated with active chromatin, but most studies have focused on the acetylation of histone tails. Various histone H3 and H4 tail acetylations mark the promoters of active genes(1). These modifications include acetylation of histone H3 at lysine 27 (H3K27ac), which blocks Polycomb-mediated trimethylation of H3K27 (H3K27me3)(2). H3K27ac is also widely used to identify active enhancers(3,4), and the assumption has been that profiling H3K27ac is a comprehensive way of cataloguing the set of active enhancers in mammalian cell types. Here we show that acetylation of lysine residues in the globular domain of histone H3 (lysine 64 (H3K64ac) and lysine 122 (H3K122ac)) marks active gene promoters and also a subset of active enhancers. Moreover, we find a new class of active functional enhancers that is marked by H3K122ac but lacks H3K27ac. This work suggests that, to identify enhancers, a more comprehensive analysis of histone acetylation is required than has previously been considered.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
31.616
6.234
108
113
Anmerkungen
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Embryonic Stem-cells; Human Genome; Transcription Factors; Super-enhancers; Lateral Surface; Sequencing Data; Genes; System; Signatures; Promoters
Sprache
Veröffentlichungsjahr
2016
HGF-Berichtsjahr
2016
ISSN (print) / ISBN
1061-4036
e-ISSN
1546-1718
Zeitschrift
Nature Genetics
Quellenangaben
Band: 48,
Heft: 6,
Seiten: 681-686
Verlag
Nature Publishing Group
Verlagsort
New York, NY
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Functional Epigenetics (IFE)
POF Topic(s)
30203 - Molecular Targets and Therapies
Forschungsfeld(er)
Helmholtz Diabetes Center
PSP-Element(e)
G-502800-001
DOI
10.1038/ng.3550
WOS ID
WOS:000376744200017
Erfassungsdatum
2016-06-27