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Hector, A.* ; Kirn, T.* ; Ralhan, A.* ; Graepler-Mainka, U.* ; Berenbrinker, S.* ; Riethmueller, J.* ; Hogardt, M.* ; Wagner, M.* ; Pfleger, A.* ; Autenrieth, I.* ; Kappler, M.* ; Griese, M.* ; Eber, E.* ; Martus, P.* ; Hartl, D.*

Microbial colonization and lung function in adolescents with cystic fibrosis.

J. Cyst. Fibros. 15, 340-349 (2016)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
With intensified antibiotic therapy and longer survival, patients with cystic fibrosis (CF) are colonized with a more complex pattern of bacteria and fungi. However, the clinical relevance of these emerging pathogens for lung function remains poorly defined. The aim of this study was to assess the association of bacterial and fungal colonization patterns with lung function in adolescent patients with CF. Microbial colonization patterns and lung function parameters were assessed in 770 adolescent European (German/Austrian) CF patients in a retrospective study (median follow-up time: 10 years). Colonization with Pseudomonas aeruginosa and MRSA were most strongly associated with loss of lung function, while mainly colonization with Haemophilus influenzae was associated with preserved lung function. Aspergillus fumigatus was the only species that was associated with an increased risk for infection with P. aeruginosa. Microbial interaction analysis revealed three distinct microbial clusters within the longitudinal course of CF lung disease. Collectively, this study identified potentially protective and harmful microbial colonization patterns in adolescent CF patients. Further studies in different patient cohorts are required to evaluate these microbial patterns and to assess their clinical relevance.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Cystic Fibrosis ; Infection ; Bacteria ; Fungi ; Lung ; Colonization; Resistant Staphylococcus-aureus; Stenotrophomonas-maltophilia Infection; Nontuberculous Mycobacteria; Pseudomonas-aeruginosa; Aspergillus-fumigatus; Fev1 Decline; Pathogens; Children; Outcomes; Epidemiology
ISSN (print) / ISBN 1569-1993
e-ISSN 1873-5010
Zeitschrift Journal of Cystic Fibrosis
Quellenangaben Band: 15, Heft: 3, Seiten: 340-349 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)