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de Jong, S.E.* ; Selman, M.H.J.* ; Adegnika, A.A.* ; Amoah, A.S.* ; van Riet, E.* ; Kruize, Y.C.M.* ; Raynes, J.G.* ; Rodriguez, A.* ; Boakye, D.* ; von Mutius, E.* ; Knulst, A.C.* ; Genuneit, J.* ; Cooper, P.J.* ; Hokke, C.H.* ; Wuhrer, M.* ; Yazdanbakhsh, M.*

IgG1 Fc N-glycan galactosylation as a biomarker for immune activation.

Sci. Rep. 6:28207 (2016)
DOI
Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
Immunoglobulin G (IgG) Fc N-glycosylation affects antibody-mediated effector functions and varies with inflammation rooted in both communicable and non-communicable diseases. Worldwide, communicable and non-communicable diseases tend to segregate geographically. Therefore, we studied whether IgG Fc N-glycosylation varies in populations with different environmental exposures in different parts of the world. IgG Fc N-glycosylation was analysed in serum/plasma of 700 school-age children from different communities of Gabon, Ghana, Ecuador, the Netherlands and Germany. IgG1 galactosylation levels were generally higher in more affluent countries and in more urban communities. High IgG1 galactosylation levels correlated with low total IgE levels, low C-reactive protein levels and low prevalence of parasitic infections. Linear mixed modelling showed that only positivity for parasitic infections was a significant predictor of reduced IgG1 galactosylation levels. That IgG1 galactosylation is a predictor of immune activation is supported by the observation that asthmatic children seemed to have reduced IgG1 galactosylation levels as well. This indicates that IgG1 galactosylation levels could be used as a biomarker for immune activation of populations, providing a valuable tool for studies examining the epidemiological transition from communicable to non-communicable diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Rheumatoid-arthritis; Antiinflammatory Activity; Humoral Responses; Gabonese Children; Serum Igg; Glycosylation; Association; Sialylation; Prevalence; Antibodies
Sprache englisch
Veröffentlichungsjahr 2016
HGF-Berichtsjahr 0
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 6, Heft: , Seiten: , Artikelnummer: 28207 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Lung Research
PSP-Element(e) G-501600-001
DOI 10.1038/srep28207
WOS ID WOS:000378107700001
Erfassungsdatum 2016-07-15
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