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Much, D. ; Beyerlein, A. ; Kindt, A. ; Krumsiek, J. ; Stückler, F. ; Rossbauer, M. ; Hofelich, A. ; Wiesenäcker, D. ; Hivner, S. ; Herbst, M. ; Römisch-Margl, W. ; Prehn, C. ; Adamski, J. ; Kastenmüller, G. ; Theis, F.J. ; Ziegler, A.-G. ; Hummel, S.

Lactation is associated with altered metabolomic signatures in women with gestational diabetes.

Diabetologia 59, 2193-2202 (2016)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
AIMS/HYPOTHESIS: Lactation for >3 months in women with gestational diabetes is associated with a reduced risk of type 2 diabetes that persists for up to 15 years postpartum. However, the underlying mechanisms are unknown. We examined whether in women with gestational diabetes lactation for >3 months is associated with altered metabolomic signatures postpartum. METHODS: We enrolled 197 women with gestational diabetes at a median of 3.6 years (interquartile range 0.7-6.5 years) after delivery. Targeted metabolomics profiles (including 156 metabolites) were obtained during a glucose challenge test. Comparisons of metabolite concentrations and ratios between women who lactated for >3 months and women who lactated for ≤3 months or not at all were performed using linear regression with adjustment for age and BMI at the postpartum visit, time since delivery, and maternal education level, and correction for multiple testing. Gaussian graphical modelling was used to generate metabolite networks. RESULTS: Lactation for >3 months was associated with a higher total lysophosphatidylcholine/total phosphatidylcholine ratio; in women with short-term follow-up, it was also associated with lower leucine concentrations and a lower total branched-chain amino acid concentration. Gaussian graphical modelling identified subgroups of closely linked metabolites within phosphatidylcholines and branched-chain amino acids that were affected by lactation for >3 months and have been linked to the pathophysiology of type 2 diabetes in previous studies. CONCLUSIONS/INTERPRETATION: Lactation for >3 months in women with gestational diabetes is associated with changes in the metabolomics profile that have been linked to the early pathogenesis of type 2 diabetes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Gestational Diabetes ; Lactation ; Metabolic Networks ; Metabolomic Profile ; Type 2 Diabetes; Breast-feeding Duration; Chain Amino-acids; Maternal Metabolism; Insulin-resistance; Glucose Challenge; Risk; Prolactin; Pregnancy; Profiles; Obese
Sprache
Veröffentlichungsjahr 2016
HGF-Berichtsjahr 2016
ISSN (print) / ISBN 0012-186X
e-ISSN 1432-0428
Zeitschrift Diabetologia
Quellenangaben Band: 59, Heft: 10, Seiten: 2193-2202 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Berlin ; Heidelberg [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research (IDF)
Institute of Computational Biology (ICB)
Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Bioinformatics and Systems Biology (IBIS)
POF Topic(s) 30201 - Metabolic Health
30205 - Bioengineering and Digital Health
30505 - New Technologies for Biomedical Discoveries
Forschungsfeld(er) Helmholtz Diabetes Center
Enabling and Novel Technologies
Genetics and Epidemiology
PSP-Element(e) G-502100-001
G-554100-001
G-505600-003
G-503800-001
G-503700-001
G-508600-006
PubMed ID 27423999
DOI 10.1007/s00125-016-4055-8
WOS ID WOS:000383122800018
Scopus ID 84978893995
Erfassungsdatum 2016-07-21
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