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Tufman, A.* ; Huber, R.M.* ; Voelk, S.* ; Aigner, F.* ; Edelmann, M.* ; Gamarra, F.* ; Kiefl, R.* ; Kahnert, K.* ; Tian, F.* ; Boulesteix, A.L.* ; Endres, S.* ; Kobold, S.*

Interleukin-22 is elevated in lavage from patients with lung cancer and other pulmonary diseases.

BMC Cancer 16:409 (2016)

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Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.

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Background: Interleukin-22 (IL-22) is involved in lung diseases such as pneumonia, asthma and lung cancer. Lavage mirrors the local environment, and may provide insights into the presence and role of IL-22 in patients. Methods: Bronchoscopic lavage (BL) samples (n = 195, including bronchoalveolar lavage and bronchial washings) were analysed for IL-22 using an enzyme-linked immunosorbent assay. Clinical characteristics and parameters from lavage and serum were correlated with lavage IL-22 concentrations. Results: IL-22 was higher in lavage from patients with lung disease than in controls (38.0 vs 15.3 pg/ml, p < 0.001). Patients with pneumonia and lung cancer had the highest concentrations (48.9 and 33.0 pg/ml, p = 0.009 and p < 0.001, respectively). IL-22 concentration did not correlate with systemic inflammation. IL-22 concentrations did not relate to any of the analysed cell types in BL indicating a potential mixed contribution of different cell populations to IL-22 production. Conclusions: Lavage IL-22 concentrations are high in patients with lung cancer but do not correlate with systemic inflammation, thus suggesting that lavage IL-22 may be related to the underlying malignancy. Our results suggest that lavage may represent a distinct compartment where the role of IL-22 in thoracic malignancies can be studied.

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