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Schötz, U. ; Heuer, S. ; Caldwell, R.B. ; Zitzelsberger, H.

Genetic and biochemical analysis of base excision repair complexes participating in radiation-induced ROS damage repair.

Radiat. Prot. Dosim. 143, 284-288 (2010)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
This work is part of the joint research project 'radiation-induced DNA damage' of the KVSF, a BMBF Initiative (maintenance of radiation biology expertise in Germany). The focus of the research is the mechanism of DNA repair, specifically damage repair aspects arising from radiation-induced reactive oxygen species production. The authors will systematically look at potential accessory proteins associated with primarily base excision repair using molecular and biochemical methods. The authors hope to gain knowledge on the initial response mechanisms to varying sources and doses of radiation. By using a highly sensitive marker system, it is intended to achieve a greater resolution of responses induced at lower doses. The work is of relevance for different human diseases caused by defects in DNA repair, e.g. spontaneous and radiation-related cancer. Beyond this, the risk of low radiation doses, for example, in the workplace is of relevance for radiation protection policy and decision-making thereof.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter dna-polymerase-beta; flap
ISSN (print) / ISBN 0144-8420
e-ISSN 1742-3406
Zeitschrift Radiation Protection Dosimetry
Quellenangaben Band: 143, Heft: 2-4, Seiten: 284-288 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Begutachtungsstatus Peer reviewed
Institut(e) Translational Metabolic Oncology (IDC-TMO)
Institute of Molecular Radiation Biology (IMS)