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Gamrekelashvili, J.* ; Giagnorio, R.* ; Jussofie, J.* ; Soehnlein, O.* ; Duchene, J.* ; Briseño, C.G.* ; Ramasamy, S.K.* ; Krishnasamy, K.* ; Limbourg, A.* ; Kapanadze, T.* ; Ishifune, C.* ; Hinkel, R.* ; Radtke, F.* ; Strobl, L.J. ; Zimber-Strobl, U. ; Napp, L.C.* ; Bauersachs, J.* ; Haller, H.* ; Yasutomo, K.* ; Kupatt, C.* ; Murphy, K.M.* ; Adams, R.H.* ; Weber, C.* ; Limbourg, F.P.*

Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.

Nat. Commun. 7:12597 (2016)
Verlagsversion Anhang DOI PMC
Open Access Gold
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A population of monocytes, known as Ly6C(lo) monocytes, patrol blood vessels by crawling along the vascular endothelium. Here we show that endothelial cells control their origin through Notch signalling. Using combinations of conditional genetic deletion strategies and cell-fate tracking experiments we show that Notch2 regulates conversion of Ly6C(hi) monocytes into Ly6C(lo) monocytes in vivo and in vitro, thereby regulating monocyte cell fate under steady-state conditions. This process is controlled by Notch ligand delta-like 1 (Dll1) expressed by a population of endothelial cells that constitute distinct vascular niches in the bone marrow and spleen in vivo, while culture on recombinant DLL1 induces monocyte conversion in vitro. Thus, blood vessels regulate monocyte conversion, a form of committed myeloid cell fate regulation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Hematopoietic Stem-cells; Green Fluorescent Protein; Dendritic Cells; Postnatal Arteriogenesis; Classical Monocytes; Lineage Commitment; Angiocrine Factors; Endothelial-cells; Vascular Niche; Lymph-nodes
Sprache englisch
Veröffentlichungsjahr 2016
HGF-Berichtsjahr 2016
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 7, Heft: , Seiten: , Artikelnummer: 12597 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Gene Vector (AGV)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-501500-003
PubMed ID 27576369
DOI 10.1038/ncomms12597
WOS ID WOS:000391871000001
Scopus ID 84984985562
Erfassungsdatum 2016-09-02
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