In addition to the DGE guideline “Fat intake and prevention of selected nutrition-related diseases” focussing on the nutrient fat (including long-chain n-3 fatty acids), this publication describes the data on the association between intake of fish as food and prevention of dyslipoproteinaemia, hypertension, coronary heart disease (CHD) and stroke. The data clearly show that regular intake of fish, particularly fatty fish, has a positive influence on the blood lipoprotein profile and reduces risk of CHD mortality and ischaemic stroke. The results confirm the recommendation of the DGE to eat fish once to twice a week.