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Geling, A.* ; Plessy, C.* ; Rastegar, S.* ; Strähle, U.* ; Bally-Cuif, L.

Her5 acts as a prepattern factor that blocks neurogenin1 and coe2 expression upstream of notch to inhibit neurogenesis at the midbrain-hindbrain boundary.

Development 131, 1993-2006 (2004)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Neurogenesis in both vertebrates and invertebrates is tightly controlled in time and space involving both positive and negative regulators. We report here that the bHLH factor Her5 acts as a prepattern gene to prevent neurogenesis in the anlage of the midbrain/hindbrain boundary in the zebrafish neural plate. This involves selective suppression of both neurogenin1 (ngn1) and coe2 mRNA expression in a process that is independent of Notch signalling, and where inhibition of either ngn1 or coe2 expression is sufficient to prevent neuronal differentiation across the midbrain-hindbrain boundary. A ngn1 transgene faithfully responds to Her5 and deletion analysis of the transgene identifies an E-box in a ngn1 upstream enhancer to be required for repression by Her5. Together our data demonstrate a role of Her5 as a prepattern factor in the spatial definition of proneural domains in the zebrafish neural plate, in a manner similar to its Drosophila homologue Hairy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Her5; hairy; midbrain-hindbrain boundary; zebrafish; neurogenesis; pre-patterning
ISSN (print) / ISBN 0950-1991
e-ISSN 1477-9129
Zeitschrift Development / Company of Biologists
Quellenangaben Band: 131, Heft: 9, Seiten: 1993-2006 Artikelnummer: , Supplement: ,
Verlag Company of Biologists
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed